HCV(CMIA)

Cudurka cagaarshowga C weli ma cadda.Marka HCV ay ku soo badato unugyada beerka waxa ay keentaa isbedel ku yimaada qaab dhismeedka iyo shaqada unugyada beerka ama waxa ay faragalisaa isku xidhka borotiinka unugyada beerka,taasi oo sababi karta hoos u dhac iyo necrosis unugyada beerka,taasi oo muujinaysa in HCV ay si toos ah u dhaawacdo beerka doorna ay ka qaadato. ee pathogenesis.Si kastaba ha ahaatee, xisaabyahano badan ayaa aaminsan in falcelinta immunopathological cell ay door muhiim ah ka ciyaari karto.Waxay ogaadeen in cagaarshow C, sida cagaarshow B, uu inta badan leeyahay CD3+ unugyo soo gala unugyadiisa.Unugyada Cytotoxic T (TC) waxay si gaar ah u weeraraan unugyada bartilmaameedka ah ee caabuqa HCV, taas oo sababi karta dhaawaca unugyada beerka.

RIA ama ELISA

Radioimmunodiagnosis (RIA) ama baaritaanka difaaca jirka ee ku xiran enzyme (ELISA) ayaa loo isticmaalay in lagu ogaado anti HCV ee serum.Sannadkii 1989, Kuo et al.la sameeyay habka radioimmunoassay (RIA) ee anti-C-100.Ka dib, Shirkadda Ortho waxay si guul leh u samaysay baaritaanka difaaca jirka ee ku xiran enzyme (ELISA) si loo ogaado anti-C-100.Labada habba waxay adeegsadaan khamiirka recombinant-ka ee fayraska lagu muujiyay (C-100-3, borotiinka lagu dhejiyay NS4, oo ka kooban 363 amino acids), nadiifinta ka dib, waxaa lagu dahaadhay qadar yar oo ah godad saxan caag ah, ka dibna lagu daro serum la tijaabiyay.Antigen-ka fayraska ayaa markaa lagu daraa anti-C-100 ee serumka la tijaabiyey.Ugu dambeyntii, isotope ama ensaymka lagu calaamadiyay mouse anti human lgG monoclonal antibody ayaa lagu daray, substrate-kana waxaa lagu daraa si loo go'aamiyo midabka.